Results | viHumans

UniProt ID

O57261

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

MVA184R ACAM3000_MVA_184

Protein Name

Interleukin-1-binding protein (Protein B16)

Organism Name

Vaccinia Virus (strain Ankara) (VACV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Vaccinia Virus> Vaccinia Virus (strain Ankara) (VACV)

RefSeq

NC_006998.1 ; AY243312.1

PubMed ID

9601507 ;

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSILPVIFLSIFFYSSFVQTFNAPECIDKGQYFASFMELENEPVILPCPQINTLSSGYNILDILWEKRGADNDRIIPIDNGSNMLILNPTQSDSGIYICI
TTNETYCDMMSLNLTIVSVSESNIDLISYPQIVNERSTGEMVCPNINAFIASNVNADIIWSGHRRLRNKRLKQRTPGIITIEDVRKNDAGYYTCVLEYIY
GGKTYNVTRIVKLEVRDKIIPSTMQLPEGVVTSIGSNLTIACRVSLRPPTTDADVFWISNGMYYEEDDGDGDGRISVANKIYMTDKRRVITSRLNINPVK
EEDATTFTCMAFTIPSISKTVTVSIT
						

Length

326

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1998

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Binds interleukin-1 and possibly interleukin-6. Could prevent these cytokines reaching their natural receptors. In consequence the inflammatory response would be diminished and virus replication enhanced.

EC

Not Available

Experimentally known GO terms

GO:0004908 ; GO:0019012 ; GO:0019048 ; GO:0019966 ; GO:0044228

Subcellular Location

Virion. Host cell surface. Note=Or secretory glycoprotein.

Domain(s)

♦DOMAIN 24 115 Ig-like 1.
♦ DOMAIN 122 212 Ig-like 2.
♦ DOMAIN 221 322 Ig-like 3.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available