Results | viHumans

UniProt ID

F5HE12

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

UL35[Gene ID: 3077429 ]

Protein Name

Tegument protein UL35

Organism Name

Human Cytomegalovirus (strain Merlin) (HHV-5) (Human Herpesvirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain Merlin) (HHV-5) (Human Herpesvirus 5)

RefSeq

Not Available

PubMed ID

15105547

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3077429

Reactome

Not Available

Sequence

							MAQGSRAPSGPPLPVLPVDDWLNFRVDLFGDEHRRLLLEMLTQGCSNFVGLLNFGVPSPVYALEALVDFQVRNAFMKVKPVAQEIIRICILANHYRNSRD
VLRDLRTQLDVLYSEPLKTRLLRGLIRLCRAAQTGVKPEDISVHLGADDVTFGVLKRALVRLHRVRDALGLRASPEAEARYPRLTTYNLLFHPPPFTTVE
AVDLCAENLSDVTQRRNRPLRCLTSIKRPGSRTLEDALNDMYLLLTLRHLQLRHALELQMMQDWVVERCNRLCDALYFCYTQAPETRQTFVTLVRGLELA
RQHSSPAFQPMLYNLLQLLTQLHEANVYLCPGYLHFSAYKLLKKIQSVSDARERGEFGDEDEEQENDGEPREAQLDLEADPTAREGELFFFSKNLYGNGE
VFRVPEQPSRYLRRRMFVERPETLQIFYNFHEGKITTETYHLQRIYSMMIEGASRQTGLTPKRFMELLDRAPLGQESEPEITEHRDLFADVFRRPVTDAA
SSSSASSSSSSASPNSVSLPSARSSSTRTTTPASTYTSAGTSSTTGLLLSSSSLSGSHGISSADLEQPPRQRRRMVSVTLFSPYSVAYSHHRRHRRRRSP
PPAPRGPAHTRFQGPDSMPSTSYGSDVEDPRDDLAENLRHL
						

Length

641

Alternate Sequence

VAR_SEQ 1 447 Missing (in isoform UL35a)

Non-standard residue

Not Available

Date of last Sequence modification

28-06-2011

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

♦Plays important role in immediate-early gene expression through interaction with UL82. Forms nuclear bodies in host nucleus, independently of PML. In turn, UL35 nuclear bodies associate with and remodel PML bodies (By similarity).
♦ Isoform UL35a promotes cytoplasmic UL82 accumulation and inhibits UL35-containing nuclear bodies formation.

EC

Not Available

Experimentally known GO terms

GO:0019033 ; GO:0039695 ; GO:0042025

Subcellular Location

♦ Isoform UL35: Virion tegument . Host nucleus . Note=Found in nuclear bodies.
♦ Isoform UL35a: Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available