One of the major challenges of computation based drug discovery is to accomplish specificity with small drug molecules at lessened cost and time while guaranteeing synthesizability and novelty at the top of the priority list. RASDD is a quick computation method for predicting drug candidates for any input DNA sequence (AT rich minor groove region). A QSAR type equation is designed by utilizing physico-chemical and structural parameters of DNA as well as drug of 20 known DNA-drug minor groove complexes. The most fascinating feature of this protocol is that it takes just a few seconds to predict the binding possibility of a drug molecule in the minor groove of DNA unlike conventional docking and scoring protocols which consume a few minutes to hours. Input DNA sequence can be scanned against a million compound database constituting natural product library and Zinc database. A user defined customized dataset or molecule can also be scanned against DNA sequence.