Onco-Regulon

Genome Browsers

Note: If only Motif Sequence is known - Start from Step 1.

If Motif Sequence and Position both are known - Go to Step 3

Select Genome Version

GRCh37 GRCh38

OncoRegulon Database is based on GRCh37

Frequency Counter

Submit sequence of interest to find Chromosome-wise frequency.

Position Finder

Gives start position of the query sequence in the genome. This serves as input for Nucleotide Sequence Extender.

You have selected autofill mode

Select Chromosome

-:Positions:-

Click start position of your target motif to go to NSE program

Nucleotide Sequence Extender

This predicts shortest unique sequences in all three possible directions.

Select Chromosome

Main Strand Complementary Strand

Start Position Of Transcription Factor Binding Site

Total no. Of Nucleotides

To get unique sequence > 30 neucleotide

Select direction of your choice.

5` 3` 3` 5` 5` 3` Direction Of Extention

Closest Sequence Finder

This tool identifies the sequence next closest to the unique sequence predicted by nucleotide sequence extender. If nucleotide extender predicts a sequence which is 'n' nucleotide long then closest sequence finder locates the occurrence of 'n-1' and 'n-2' sequences in the whole genome. This will help the user to identify the sequence where the drug may bind non-specifically.

Select Counter

5` 3` 3` 5` 5` 3` Direction Of Contraction

Additional Analysis

:- Predicts the structural features of DNA.
:- Generates DNA 3D structure for a given DNA sequence.
:- Performs docking & scoring of DNA and ligand in a fully automated mode.
:- Estimates the binding free energy of a DNA-ligand (minor groove binder) complex.