# -*- coding: utf-8 -*-
"""
Created on Wed Nov 13 13:12:14 2019

@author: ASUS
"""

#program converts FASTA file format[uni"\t"seq] to lowercase n uppercase according to g d s l properites n will make 15 different combinations of gdsl

g=['E','I','K','L','M','P','Q','R','T','V']
d=['C','H','K','N','Q','R','S','T','W','Y']
s=['A','C','D','G','I','M','N','S','T','V']
l=['A','D','E','F','H','K','M','P','S','W','Y']
gd=['K','Q','R','T']
gs=['I','M','T','V']
gl=['E','K','M','P']
ds=['C','N','S','T']
dl=['H','K','S','W','Y']
ls=['A','D','M','S']
gds=['T']
dsl=['S']
lgd=['K']
slg=['M']
gdsl=['']
newstring1=""
newstring2=""
newstring3=""
newstring4=""
newstring5=""
newstring6=""
newstring7=""
newstring8=""
newstring9=""
newstring10=""
newstring11=""
newstring12=""
newstring13=""
newstring14=""
newstring15=""

fo1=open(r'G.fasta','w+')
fo2=open(r'D.fasta','w+')
fo3=open(r'S.fasta','w+')
fo4=open(r'L.fasta','w+')

fp1=open( r'file')
for line in fp1:
  row = line.rstrip('\n').split('\t')
  uni = row[0]


  for aa in row[1]:
      if aa in g:
          newstring1+=aa
      else:
          newstring1+=(aa.lower())
  fo1.write(row[0]+"\n"+str(newstring1)+"\n")
  fo1.read()
  newstring1=""

fp2=open( r'file')
for line in fp2:
  row = line.rstrip('\n').split('\t')


  for aa in row[1]:
      if aa in d:
          newstring2+=aa
      else:
          newstring2+=(aa.lower())
  fo2.write(row[0]+"\n"+str(newstring2)+"\n")
  newstring2=""

fp3=open( r'file')
for line in fp3:
  row = line.rstrip('\n').split('\t')


  for aa in row[1]:
      if aa in s:
          newstring3+=aa
      else:
          newstring3+=(aa.lower())
  fo3.write(row[0]+"\n"+str(newstring3)+"\n")
  newstring3=""

fp4=open( r'file')
for line in fp4:
  row = line.rstrip('\n').split('\t')


  for aa in row[1]:
      if aa in l:
          newstring4+=aa
      else:
          newstring4+=(aa.lower())
  fo4.write(row[0]+"\n"+str(newstring4)+"\n")
  newstring4=""